Hotels on the East Shore are centrally located. From here it’s easiest to explore the island. You can get to the North Shore as quickly as you can get to the South Shore.
East Shore
The Royal Sonesta Kaua'i Resort Lihue -
https://www.sonesta.com/royal-sonesta/hi/lihue/royal-sonesta-kauai-resort-lihue
Sheraton Kauai Coconut Beach Resort -
https://www.marriott.com/en-us/hotels/lihsk-sheraton-kauai-coconut-beach-resort/overview/
Aston Islander on the Beach -https://www.aquaaston.com/hotels/aston-islander-on-the-beach
Kauai Beach Resort - https://www.outrigger.com/hawaii/kauai/outrigger-kauai-beach-resort-spa
Courtyard by Marriott - https://www.marriott.com/hotels/travel/lihku-courtyard-kauai-at-coconut-beach/
Waipouli Resort - http://www.waipoulibeachresort.com
Hilton Garden Inn Kauai Wailua Bay - https://hiltongardeninn3.hilton.com/en/hotels/hawaii/hilton-garden-inn-kauai-wailua-bay-LIHWBGI/about/amenities.html
South Shore
Koloa Landing Resort at Po'ipu, Autograph Collection - https://www.marriott.com/en-us/hotels/lihak-koloa-landing-resort-at-poipu-autograph-collection/overview/
Sheraton, now owned by Marriot - http://www.sheraton-kauai.com
South Shore - Koa Kea, Poipu Beach
Grand Hyatt Kauai
https://www.hyatt.com/en-US/hotel/hawaii/grand-hyatt-kauai-resort-and-spa/kauai