The closest airport is John Wayne (SNA) however, it's a small airport so you'll most likely have a connecting flight if you're traveling from the East Coast. You'll find plenty of direct flights into LAX which is a 50 mile drive to Orange County. If you need to rent a car, Uber, or Lyft down, feel free to reach out to Brian to offer tips on how to navigate LAX.
There's a variety of hotels that you can book, ranging from modest motels to luxury resorts. San Clemente is a sleepy beach town so if you're interested in staying the weekend to enjoy what Orange County has to offer, we would recommend booking a hotel in Laguna Beach or Newport Beach.
If you're interested in renting an Airbnb, we would recommend looking in nearby residential cities including Aliso Viejo, Mission Viejo, Laguna Hills, San Juan Capistrano, San Clemente, or Ladera Ranch.