From Cold Spring, Fishkill, Peekskill & points south:
Take Route 9 North towards Poughkeepsie; get off the Main Street Exit, at end of ramp make a left on Main Street; pass one traffic light at the entrance to the Poughkeepsie train station; go straight and make a right on North Water Street. The museum building will be on your left. The parking lot entrance is past the building on the left.
From the Newburgh/Beacon Bridge:
Follow the directions from Fishkill above.


From the Mid-Hudson Bridge:
Cross the bridge, at the first traffic light make a left. Continue to the first stop sign, make another left. Follow the road around and continue to the next light (this is the intersection of Clover and Main Street); make a left onto Main Street. Continue on this road (you will past the entrance to the Poughkeepsie train station and one traffic light). Make a right onto North Water Street; the museum building will be on your left.

From Pawling, Millbrook, Wingdale and points east:
Take Route 44/55 West to Poughkeepsie. As Route 44/55 gets closer to the heart of Poughkeepsie, the road expands to 3-4 lanes (arterial). As Route 44/55 passes Market Street/Civic Center/Poughkeepsie Grand Hotel and curves to the left, get into the right lane in preparation to make a right turn at the exit light. The next light is the intersection of Route 44/55 and Main Street. Make a right onto Main Street. Stay on this road until you reach North Water Street (you will pass signs for entering Route 9 South and the Poughkeepsie train station); make a right on North Water Street; the museum building will be on your left.

From Rhinebeck, Hyde Park, Red Hook & points north:
Take Route 9 South towards Poughkeepsie. Take Water St Exit on right 1/4 mile after you pass Marist College. At top of ramp, turn right onto Hoffman St; cross the bridge over the railroad tracks and turn left onto North Water St. Go down hill. MHDM parking lot will be on your right.

MHDM is located on the Poughkeepsie Waterfront across the street from the Poughkeepsie Train Station.

From New York City:
Take the Hudson River Line to the Poughkeepsie Station.

From Albany:
Take Amtrack from Albany-Rensselaer Station to the Poughkeepsie.