Trains
There are two main Amtrak stops, one 80 minutes west of Wilmington in Albany and the second 30 minutes east in Brattleboro.
Planes
There are three main airports. Albany in the west by 80 minutes. Bradley (near Hartford, CT) south at 100 minutes. And Boston east at 2.5 hour. We've found that Bradley has the best balance of available flights / affordability / distance. We tend to avoid Boston because of the traffic.
Automobile
Driving to Wilmington is often an efficient bet with fewer logistics.