Other airport options include San Francisco (SFO) & Oakland (OAK), though we suggest flying in/out of Sacramento - depending on time of day, traffic is a lot easier from SAC!
For reference, we will be staying at the Andaz in Downtown Napa (a Hyatt hotel). The hotel is centrally located in the lively "west end" district of downtown Napa, within walking distance of over 20 tasting rooms featuring some of the best wines in the valley, art, entertainment, galleries, local artisans and gourmet dining options. Plus, it has a great rooftop terrace for drinks.
There are plenty of other nearby hotels in Downtown Napa to fit every need and budget, including:
The Westin Verasa Napa
River Terrace Inn
Bel Abri Napa Valley Inn
Embassy Suites By Hilton Napa Valley
Hampton Inn & Suites Napa
Sacramento International offers four rental car companies within the airport:
Avis - www.avis.com / 916.922.5601
Budget - www.budget.com / 800.763.2999
Hertz - www.hertz.com / 800.654.3131
National - www.nationalcar.com / 800.227.7366