From the North (starting in Burlington, VT):

Take I-87 S to I-84. At Scranton, PA take I-81 S to I-80 W to PA-147 S. Then take PA-304 W, New Berlin Hwy, US-522 S and Back Maitland Rd to Shade Mountain Farm.

From the South (starting in Richmond, VA):

The most direct route to Lewistown during low traffic times is via I-95 N, 1-495 N past Washington DC, then I-270 N to US-15 N. Then take US-22 W to the US 22 Business W exit toward Lewistown.

During heavy traffic times, I-95 N to Hwy 17 N

at Fredericksburg, VA may be a better option to avoid Washington DC. From Hwy 17 N, take PA-75 N, then US-522 N to E Charles St exit in Lewistown.

From the East (starting in New York, NY):

Follow I-78 W, I-81 S and US-22 W/US-322 W to US-22 BUS W in Derry Township. Take the US 22 Business W exit toward Lewistown.

From the West (starting in Pittsburgh, PA):

Take I-376 E to US-22 E in Monroeville. Take I-99 N to US-322 E at State College. Take the E Charles St exit in Lewistown. Or, in Monroeville, stay on US-22 E to US-522N and take the E Charles St exit in Lewistown.