GSP (Greenville Spartanburg Airport) is the closest airport to Spartanburg, about a 25 minute drive

CLT (Charlotte Douglass Airport) is in Charlotte and about an hour and 15 minute drive

Other local hotels:

Spartanburg Marriott

https://www.marriott.com/en-us/hotels/spamc-spartanburg-marriott/overview/

Hilton Garden Inn

https://www.hilton.com/en/hotels/gspspgi-hilton-garden-inn-spartanburg/