Chicago O'Hare (ORD) or Chicago Midway (MDW) are each about a 2-hour drive from Notre Dame. Once arriving in Chicago, you can either drive to South Bend or take the "L" into the city and the South Shore train to South Bend.

Indianapolis International Airport (IND) is about a 2.5 hour drive South of Notre Dame.

Grand Rapids Airport (GRR) is about 2-hours North of Notre Dame.

South Bend International (SBN) is 15-minutes from Notre Dame, however, it has limited flights that tend to be expensive.

Check out this website for more information.